Molecular Science for Supra Functional Systems - Development of Advanced Methods for Exploring Elementary Process

(A03) Supra Functional Systems in Biomolecules

高次系A01 高次系A02
 Our challenge is to develop new spectroscopic methodologies to observe protein dynamics that have been inaccessible by any conventional techniques. A deeper understanding of the nature of protein dynamics will be led based on analyzing the behavior of protein, both in vitro and in vivo. We aim to open a new field in molecular science, by combining spectroscopic techniques to study molecular structure and imaging techniques to study cell structure.
TOPICS
Functionally-important dynamics of proteins revealed by time-resolved spectroscopy

時間分解分光法で観るタンパク質の機能に関わるダイナミクス
● Theme

(1) Elucidation of the molecular mechanism of allosteric proteins based on the observation of protein dynamics.
(2) Spectroscopic imaging of intracellular biomolecules and elucidation of the reaction mechanism.

● Keywords

Protein Dynamics, Time-Resolved Spectroscopy, Space-Resolved Spectroscopy, Single-Molecule Spectroscopy

● Research Area

Spectroscopy, Microscopy, Biomolecular Science

● Planned Research Members

Elucidation of structural basis of dynamically-driven protein allostery by time-resolved resonance Raman spectroscopy

Leader Yasuhisa Mizutani (Osaka University, Professor)

Haruto Ishikawa (Osaka University, Associate Professor)

Misao Mizuno (Osaka University, Assistant Professor)

Dynamic multi-photon spectroscopic imaging of intracellular biomolecules using a white laser source

Leader Hideaki Kano (The University of Tokyo, Associate Professor)

Structure and function relationship of Enzymes Studied by Single-Molecule Spectroscopy at Liquid-Helium Temperature

Leader Michio Matsushita (Tokyo Institute of Technology, Associate Professor)

Satoru Fujiyoshi (Tokyo Institute of Technology, Assistant Professor)

Three-dimensional super-resolution spectromicroscopy to trace inter-protein interactions and morphological changes in photosynthetic membranes on spatial and temporal domains

Leader Shigeichi Kumazaki (Kyoto University, Associate Professor)

● Proposed Research Subjects

Analysis of the single-molecular gating dynamics of ion channels with the Diffracted X-ray Tracking Method

Leader Hirofumi Shimizu (University of Fukui, Senior Assistant Professor)

Yoshimitsu Aoki (Keio University, Associate Professor)

Masayuki Iwamoto (University of Fukui, Assistant Professor)

Takashi Konno (University of Fukui, Associate Professor)

Shigetoshi Oiki (University of Fukui, Professor)

Molecular science of sensory rhodopsins: Relationship between function and structural changes

Leader Yuki Sudo (Nagoya University, Associate Professor)

Study on reaction dynamics of proteins that reaches from micro to macro by time-resolved spectroscopy

Leader Keiichi Inoue (Nagoya Institute of Technology, Assistant Professor)

Theoretical studies on proton and hydrogen bonding in biological molecules

Leader Hirofumi Sato (Kyoto University, Professor)

Single-molecule FRET measurement of rotary motor protein dynamics in living cells

Leader Ryota Iino (The University of Tokyo, Lecturer)

Physicochemical properties of Low barrier hydrogen bonds

Leader Hironari Kamikubo (Nara Institute of Science and Technology, Associate Professor)

Exploring functionally related morphological changes of KcsA by NMR spectroscopy

Leader Shin-ichi Tate (Hiroshima University, Professor)

Physiological Molecular Science of Membrane Proteins

Leader Takashi Ogura (University of Hyogo, Professor)

Satoru Nakashima (University of Hyogo, Associate Professor)

Sachiko Yanagisawa (University of Hyogo, Assistant Professor)

Development of an algorithm to predict hydration structure on hydrophobic surface of proteins

Leader Masayoshi Nakasako (Keio University, Professor)

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