| 東京工業大学 科学技術創成研究院 化学生命科学研究所 |
物質理工学院 応用化学系 （応用化学コース） |
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小池 隆司 特定准教授 |
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| 所属 ＆ 連絡先 | ||
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東京工業大学 科学技術創成研究院 化学生命科学研究所 穐田研究室 住所：〒226-8503 横浜市緑区長津田町4259, R1-27
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受賞・助成など
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| 研究テーマ | ||
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光触媒は光エネルギーを利用して通常では困難な化学プロセスを実現できる可能性をもっています。我々のグループでは、遷移金属錯体や有機分子可視光レドックス触媒の特異な反応性に着目し、高効率で高い選択性をもつ新しい触媒的分子変換技術の開発を目指しています。 専門：有機金属化学・分子触媒化学・有機合成化学 |
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| 論文リスト | ||
Energy transfer-driven regioselective synthesis of functionalized phenanthridines by visible-light Ir photocatalysis Org. Chem. Front., 2020, 7, 1243-1248.  Fluoroalkanesulfinate Salts as Dual Fluoroalkyl and SO2 Sources: Atom-Economical Fluoroalkyl-Sulfonylation of Alkenes and Alkynes by Photoredox Catalysis Org. Lett., 2020, 22, 2801-2805.  Frontiers in Radical Fluoromethylation by Visible-Light Organic Photocatalysis (Special Collections: 100th Annual Meeting of the Chemical Society of Japan) Asian J. Org. Chem., 2020, 9, 529-537. (Frontispiece)   高い還元力を有する芳香環光レドックス触媒（特許出願） 特願2019-160380, 2019年9月3日（出願人 東京工業大学） Keto-Difluoromethylation of Aromatic Alkenes by Photoredox Catalysis: Step-Economical Synthesis of α-CF2H-Substituted Ketones in Flow ACS Catal., 2019, 9, 6555-6563. (SYNFACTSにハイライトされました)  T. Koike, M. Akita Recent Progress in Photochemical Radical Di- and Mono-Fluoromethylation Org. Biomol. Chem., 2019, 17, 5413-5419.  T. Koike Visible-Light Photoredox Catalysis: New Strategies for Radical Reactions J. Synth. Org. Chem., Jpn., 2019, 77, 414-423.  Visible Light-Triggered Monofluoromethylation of Alkenes by Strongly Reducing 1,4-Bis(diphenylamino)naphthalene Photoredox Catalysis ACS Catal., 2019, 9, 4382-4387.  Photocatalytic Introduction of Fluorinated Groups Science of Synthesis: Photocatalysis in Organic Synthesis; B. Konig, Ed., 2019, 559-574. Strongly Reducing (Diarylamino)anthracene Catalyst for Metal-Free Visible-Light Photocatalytic Fluoroalkylation ACS Catal., 2018, 8, 9408-9419. (Front Coverに選ばれました)   Photoredox Radical C－H Oxygenation of Aromatics with Aroyloxylutidinium Salts Org. Chem. Front., 2018, 5, 1406-1410. (Front Coverに選ばれました)   New Horizons of Photocatalytic Fluoromethylative Difunctionalization of Alkenes Chem, 2018, 4, 409-437.  Metal-free di- and tri-fluoromethylation of alkenes realized by visible-light-induced perylene photoredox catalysis Chem. Sci., 2017, 8, 6375-6379. （有機合成化学協会誌４月号の「新しい合成」で紹介されました）  Photoredox-Catalyzed Oxytrifluoromethylation of Allenes: Stereoselective Synthesis of 2-Trifluoromethylated Allyl Acetates Chem. Commun., 2017, 53, 4681-4684. (Back Coverに選ばれました)   Photocatalytic Trifluoromethylthiolation of Aromatic Alkenes Associated with Hydroxylation and Alkoxylation Asian J. Org. Chem., 2017, 6, 445-448. (Front Coverに選ばれました) (Asian JOC Readers' Choice 2019に選ばれました)   多環芳香族炭化水素を光触媒とするフルオロメチル基含有化合物の製造方法（特許出願） 特願2017-0028880, 2017年2月20日（出願人 旭硝子株式会社・東京工業大学） Fine Design of Photoredox Systems for Catalytic Fluoromethylation of Carbon－Carbon Multiple Bonds Acc. Chem. Res., 2016, 49, 1937-1945.  A Versatile Strategy for Difunctionalization of Carbon－Carbon Multiple Bonds by Photoredox Catalysis Org. Chem. Front., 2016, 3, 1345-1349.  Aminohydroxylation of Olefins with Iminopyridinium Ylides by Dual Ir Photocatalysis and Sc(OTf)3 Catalysis Tetrahedron, 2016, 72, 7813-7820.  Diastereoselective Synthesis of CF3- and CF2H‐Substituted Spiroethers from Aryl-Fused Cycloalkenylalkanols by Photoredox Catalysis J. Org. Chem., 2016, 81, 7064-7071. (Org. Process. Res. Dev. Vol. 21でハイライトされました)  Combination of Organotrifluoroborates with Photoredox Catalysis Marking a New Phase in Organic Radical Chemistry Org. Biomol. Chem., 2016, 14, 6886-6890. (Inside Cover & Hot Articlesに選ばれました)   Radical Pentafluorosulfanylphenylation of Styrenes by Photoredox Catalysis Synlett, 2016, 27, 736-740. (Synform Newsでハイライトされました) 
Oxydifluoromethylation of Alkenes by Photoredox Catalysis: Simple Synthesis of CF2H-Containing Alcohols Chem. Eur. J., 2016, 22, 1262-1265. （有機合成化学協会誌12月号の「新しい合成」で紹介されました） 
Trifluoromethylation of Aromatic Alkenes by Visible-light-driven Photoredox Catalysis: Direct Conversion of Alkenes to 3-Trifluoromethyl-1-propenyl and 1,3-Bis(trifluoromethyl)-1-propenyl Derivatives J. Fluorine Chem., 2015, 179, 83-88. 
Photoredox-Catalyzed Stereoselective Conversion of Alkynes into Tetrasubstituted Trifluoromethylated Alkenes Angew. Chem. Int. Ed., 2015, 54, 12923-12927. 
Anti-Diastereoselective Synthesis of CF3-Containing Spirooxazolines and Spirooxazines via Regiospecific Trifluoromethylative Spirocyclization by Photoredox Catalysis Org. Lett., 2015, 17, 3710-3713. （Synfactsでハイライトされました） 
Regiospecific Intermolecular Aminohydroxylation of Olefins by Photoredox Catalysis Chem. Eur. J., 2015, 21, 11677-11680. 
ジフルオロメチル基含有アルコールの製造法（特許出願） 特願2015-045831, 2015年3月9日（出願人 東ソー・エフテック株式会社・東京工業大学） Alkyl- and Aryl-thioalkylation of Olefins with Organotrifluoroborates by Photoredox Catalysis Org. Chem, Front., 2015, 2, 319-323. （Inside Coverに選ばれました） （Most downloaded articles for the last 30 daysに選ばれました）   Redox-economical Radical Generation from Organoborates and Carboxylic Acids by Organic Photoredox Catalysis RSC Adv., 2015, 5, 21297-21300. 
1，2－アミノアルコール骨格を持つ化合物の製造法（特許出願） 特願2014-241563, 2014年11月28日（出願人 東京工業大学） Visible-Light-Induced Redox Reactions by Ruthenium Photoredox Catalyst (in "Ruthenium in Catalysis") Top. Organomet. Chem., 2014, 48, 371-396. （Popular content within this publicationに選ばれました） Recent progress in transition-metal-catalyzed trifluoromethylation of olefins using electrophilic CF3 reagents J. Fluorine. Chem., 2014, 167, 30-36. （Most Downloaded Journal of Fluorine Chemistry Articlesに選ばれました） 
Hydroaminomethylation of Olefins with Aminomethyltrifluoroborate by Photoredox Catalysis Adv. Synth. Catal., 2014, 356, 2749-2755. （Front Coverに選ばれました） （Most Accessed in 9/2014に選ばれました）   Visible-light radical reaction designed by Ru- and Ir-based photoredox catalysis Inorg. Chem. Front., 2014, 1, 562-576. （Front Coverに選ばれました） （Most downloaded articles for the last 30 daysに選ばれました） （Top 10 most-read articles in Q3(July-September) of 2014に選ばれました） （Top 10 most-read articles in Q4(October-December) of 2014に選ばれました） （Top 10 most-read articles in Q1(January-March) of 2015に選ばれました）   Combining Photoredox-Catalyzed Trifluoromethylation and Oxidation with DMSO: Facile Synthesis of a-Trifluoromethylated Ketones from Aromatic Alkenes Angew. Chem. Int. Ed., 2014, 53, 7144-7148. （Frontispieceに選ばれました）   Direct C-H Trifluoromethylation of Di- and Trisubstituted Alkenes by Photoredox Catalysis (Thematic Series on "Organic Synthesis using Photoredox Catalysis") Beilstein J. Org. Chem., 2014, 10, 1099-1106. （Most Accessed Paper (last 30 days)に選ばれました） 
トリフルオロメチル基含有オキサジン類及びその製造法（特許出願） 特願2014-036832, 2014年2月27日（出願人 東ソー・エフテック株式会社・東京工業大学） Trifluoromethylation by Visible-Light-Driven Photoredox Catalysis Top. Catal., 2014, 57, 967-974 (Invited by ISHHC-16). Highly Regio- and Diastereoselective Synthesis of CF3-Substituted Lactones via Photoredox-Catalyzed Carbolactonization of Alkenoic Acids Org. Lett., 2014, 16, 780-783. 
Visible-light-induced Photoredox Catalysis: An Easy Access to Green Radical Chemistry Synlett 2013, 24, 2492-2505. 
Visible-Light-Induced Hydroalkoxymethylation of Electron-Deficient Alkenes by Photoredox Catalysis Chem. Commun., 2013, 49, 7249-7251. （有機合成化学協会誌2014年1月号の「新しい合成」で紹介されました） 
Photochromic Organometallics: Redox-Active Iron and Ruthenium Complexes with Photochromic DTE Ligand (Chapter 11) New Frontiers in Photochromism, Springer, 2013, 205-224. （Popular content within this publicationに選出されました） Intermolecular Aminotrifluoromethylation of Alkenes by Visible-Light-Driven Photoredox Catalysis Org. Lett., 2013, 15, 2136-2139. （月間 Most Read Articles（4月）のTop 20に選出されました） （有機合成化学協会誌9月号の「新しい合成」で紹介されました） （Organic Chemistry Portalで紹介されました） 
トリフルオロメチル基含有アミノ化合物の製造法（特許出願） 特願2013-029911, 2013年2月19日（出願人 東ソー・エフテック株式会社・東京工業大学） Visible-light-induced Synthesis of a Variety of Trifluoromethylated Alkenes from Potassium Vinyltrifluoroborates by Photoredox Catalysis Chem. Commun., 2013, 49, 2037-2039. 
Visible-Light-induced Selective Generation of Radicals from Organoborates by Photoredox Catalysis Adv. Synth. Catal. 2012, 354, 3414-3420. （月間アクセス数（12月）のトップ10に入りました） 
Visible-light-driven Oxidation of 1,3-Dicarbonyl Compounds via Catalytic Disproportionation of TEMPO by Photoredox Catalysis Chem. Lett. 2012, 41, 999-1001. 
Three-component Oxytrifluoromethylation of Alkenes: Highly Efficient and Regioselective Difunctionalization of C=C Bonds Mediated by Photoredox Catalysts Angew. Chem. Int. Ed., 2012, 51, 9567-9571. （Advances in EngineeringのChemical Engineering欄で紹介されました） 
Sunlight-driven Synthesis of gamma-Diketones via Oxidative Coupling of Enamines with Silyl Enol Ethers Catalyzed by [Ru(bpy)3]2+ Chem. Commun., 2012, 48, 5355-5357. （有機合成化学協会誌10月号の「新しい合成」で紹介されました） 
Theoretical Study on the Photocyclization Mechanism of Diarylethenes with Transition-Metal Substituents Bull. Chem. Soc. Jpn., 2012, 85, 679-686. Color Change of Redox-active Organometallic Dithienylethene Complexes by Photochemical and Redox Processes Dyes and Pigments 2012, 92, 854-860. Photo- and Electro-chromic Organometallics with Dithienylethene (DTE) Linker, L2CpM-DTE-MCpL2: Dually Stimuli-Responsive Molecular Switch Dalton Trans., 2011, 40, 10643-10657 (Dalton Trans. 40th anniversary issue). Making Organometallic Molecular Wire via Oxidative Ligand Coupling Dalton Trans., 2011, 40, 8089-8091. 3,5-Bis(diphenylphosphinoethyl)pyrazolate ligand (PNNPC2) and its dirhodium complexes: comparison with related quadridentate dinucleating diphenylphosphinomethyl (PNNPPy) and phthalazine derivatives (PNNPPh) Inorg. Chim. Acta 2011, 374, 489-498. (special issue dedicated to Prof. W. Kaim). Dirhodium Complexes Bridged by Bis(diphenylphosphino)phthalazine (PNNPPh): Central Ring Size and Charge Effects as Compared with the Pyrazolate Derivative (PNNPPy) Organometallics, 2010, 29, 6493－6502. Reversible, Fine Performance Tuning of Organometallic Molecular Wire by Addition, Ligand Replacement and Removal of Dicobalt Fragments Eur. J. Inorg. Chem., 2010, 23, 3571-3575 . 2-Dimensional molecular wiring based on toroidal delocalization of hexaarylbenzene. Chem. Commun., 2010, 46, 4529-4531. Photochromic Organometallics with a Dithienylethene (DTE) Bridge, M-CC-DTE-CC-M [M= MCp*(dppe)]: Photoswitchable Molecular Wire (M= Fe) vs. Dual Photo- and Electro-chromism (M= Ru). Chem. Eur. J., 2010, 16, 4762-4776. Photoinduced Oxyamination of Enamines and Aldehydes with TEMPO Catalyzed by [Ru(bpy)3]2+ Chem. Lett., 2009, 38, 166－167. 
Remarkable Switching Behavior of Bimodally Stimuli-responsive Photochromic Dithienylethenes with Redox-active Organometallic Attachements Chem. Commun. 2008, 5812-5814. Organometallic Chemistry of Polycarbon Species: From Clusters to Molecular Devices Dalton Trans. 2008, 3523-3530. (invited Perspective; cover) Aerobic Oxidation of Alcohols with Bifunctional Transition Metal Catalysts Bearing C-N Chelate Ligands Chem. Asian J., 2008, 3, 1479－1485. Synthesis and Reactivities of Cp*Ir Amide and Hydride Complexes Bearing C-N Chelate Ligands Organometallics, 2008, 27, 2795－2802. Aerobic Oxidative Kinetic Resolution of Racemic Secondary Alcohols with Chiral Bifunctional Amido Complexes Angew. Chem. Int. Ed., 2008, 47, 2447-2449 (selected as "Very Important Papers"). Synthesis and Properties of Alkylruthenium Complexes Bearing Primary and Secondary Amine Ligands J. Organomet. Chem., 2007, 692, 408-419. Reaction of 16-Electron Ruthenium and Iridium Amide Complexes with Acidic Alcohols: Intramolecular C-H Bond Activation and the Isolation of Cyclometalated Complexes Organometallics, 2005, 24, 724-730. Mechanistic Aspects of Formation of Chiral Ruthenium Hydride Complexes from 16-Electron Ruthenium Amide Complexes and Formic Acid: Facile Reversible Decarboxylation and Carboxylation Adv. Synth. Catal., 2004, 346, 37-41. Stereoselective Synthesis of Optically Active α-Hydroxy Ketones and anti-1,2-Diols via Asymmetric Transfer Hydrogenation of Unsymmetrically Substituted 1,2-Diketones Org. Lett., 2000, 2, 3833-3836. |
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| 記事・書籍 | ||
S‐(Trifluoromethyl)dibenzothiophenium Tetrafluoroborate Encyclopedia of Reagents for Organic Synthesis, 2018 (DOI: 10.1002/047084289X.rn01212.pub2) 可視光（太陽光）促進有機金属触媒反応：フォトレドックス触媒と機能分担型二核錯体触媒系 有機合成化学会誌 2014, 72 (5月号), 538-547. 高原子価有機銅(III)種によるアリール化反応（Review de Debut） 有機合成化学会誌 2014, 72 (4月号), 431-432. スポットライトを浴びる酸化還元反応ーフォトレドックス触媒によるトリフルオロメチル化反応 化学 , 2013年9月号, p64-65. 機能性有機金属分子ワイヤーの合成とその可能性 MATERIAL STAGE 2013, 12(12), 9－12. フォトクロミックオルガノメタリックス フォトクロミズムの新展開と光メカニカル機能材料（シーエムシー出版）2011, 47-53. π共役系架橋配位子を有する有機金属分子ワイヤー 化学工業, 2009, 60, 827-835. ”動的”なピンサー型金属錯体：アルコールとアンモニアから第一級アミンをつくる！ 化学, 2009年4月号, 2009年の化学：注目の論文 | ||
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